Requirement of Fc-Fc Gamma Receptor Interaction for Antibody-Based Protection against Emerging Virus Infections

Identification of therapeutics against emerging and re-emerging viruses remains a continued priority that is only reinforced by the recent SARS-CoV-2 pandemic. Advances in monoclonal antibody (mAb) isolation, characterization, production make it viable option for rapid treatment development. While mAbs are traditionally screened selected based on potency neutralization vitro, clear additional factors contribute to vivo efficacy mAb beyond viral neutralization. These include interactions with Fc receptors (FcRs) complement can enhance neutralization, clearance infected cells, opsonization virions, modulation innate adaptive immune response. In this review, we discuss studies, primarily using mouse models, identified role Fc-Fc?R optimal antibody-based protection virus infections.